Chancellors Club Teaching & Research Awardees

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder, characterized by the formation and growth of numerous fluid-filled cysts within the kidneys. Although the cysts are benign; their relentless growth leads to inflammation, fibrosis, massively enlarged kidneys, and progressive decline in renal function. Professor Wallace’s laboratory investigates cellular mechanisms responsible for aberrant cell proliferation, cyst fluid accumulation due to transepithelial Cl secretion, and pathways involved in renal inflammation, extracellular matrix remodeling and deposition, and fibrosis.